zenbis

Zenbis refers to persons with sensitive bowel who suffer from bloating, irregular transit, abdominal discomfort and helps the normalization of bowel motility.
Zenbis is a total new approach to deal with bowel discomforts.
Zenbis, due to its probiotic act, is effective in depth for restoration and normalization of the intestinal flora.
Zenbis contains a specific probiotic: lactobacillus plantarum 299V with documented effect on bowel disturbances.

Many people-in majority women face such intensive symptoms that occur periodically, last several days, even weeks and are repeated regularly.
The cause of these symptoms is not known. They do not affect the physiology of the bowel but they disturb its function and as a result, the bowel becomes irritated and contracts irregular. These symptoms mostly effect and downgrade the quality of people’s life. There are many reasons that can cause such disorders, such as psychological (stress, anxiety), dietary, specific medicines.

Product Composition
Lp299v belongs to the genus Lactobacillus. The species Lactobacillus plantarum belongs to the natural flora of the mucous in the oral and intestinal mucosa of healthy humans.

Origin
The strain Lp299v was isolated from human intestinal mucosa. It is deposited at the DSM collection (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH) under number DSM 9843. Its usefulness for treating and preventing gastrointestinal tract infections and diseases is the subject of a patent (patent No. WO 9301823) based on the ability to colonize human intestinal mucosa.

Survival in and colonization of the gastrointestinal tract
To be effective, a probiotic must survive the passage of the stomach and small intestine and be viable on arrival at the large intestine. In vitro tests have demonstrated the resistance of Lp299v to gastric acidity and biliary salts, corresponding to the two critical stages for survival of micro-organisms.

Specific mechanism of adhesion to mucosal cells
Lp299v is capable of colonizing the mucosa of the human colon in vivo.

Pharmacology
Action on the intestinal microflora.
-Increasing the concentration of carboxylic acids.
-Increasing the Lactobacillus population.
-Inhibition of adhesion of Enterobacteria in the intestinal mucosa.
-Inhibition of the growth of potential pathogenic agents.

Presentation
Lp299v in sachet form which contain 10 billion live bacteria per sachet.

Regulatory status
Lp299v is circulated as a product for special medical use.

Recommended usage
Lp299v is recommended for restoration and normalization of the intestinal flora, with documented effect on irritable bowel syndrome.

Probiotics
Live micro-organisms which, when administered in adequate concetrations, confer a health benefit on the host.
In the last fifteen years, clinical research on probiotics has accelerated. The modes of action have been more and more precisely elucidated, and new therapeutic applications are being developed.
Certain aspects of the modes of action of probiotics remain to be determined. Today, it appears clear that they can induce a beneficial change in the intestinal microflora when it is dominated by potentially pathogenic agents.

Main species and modes of action
The main probiotics
The best-known probiotics are:
• the lactic bacteria: Lactobacilli, streptococci, lactococci.
• the Bifidobacteria: Bifidobacterium bifidum, B. longum, B. breve
• the yeasts: Saccharomyces boulardii

Effect on the two natural defence systems
Probiotics have the capacity to maintain the balance of the intestinal microflora and to influence the immune system in situ.
For many years, studies have been conducted on different strains. They suggest that probiotics are capable of preventing infection by pathogens, either by modulation of the immune system or by other modes of action such as competitive exclusion.

Particularities of the Lactobacilli
The Lactobacilli form part of the normal microflora of the mouth and the intestine. The majority of them can adhere to the colon cells. In addition, they are the group most studied for their potential therapeutic qualities and their applications in probiotic preparations.